Comparing E4-positive elderly controls with E4-positive younger LOAD cases

 
   Lead Investigator:    Alan Renton
   Institution      :    Mt Sinai
   E-Mail           :    alan.renton@mssm.edu
   Proposal ID      :    587



   Proposal Description:
   The APOE E4 allele is the strongest known genetic risk factor for late-onset      Alzheimer???s disease (LOAD). However, a subset of E4-positive individuals        reach old age without developing LOAD, suggesting that protective factors are     involved. Using next generation sequencing data, we shall undertake a             genome-wide association study, comparing E4-positive elderly controls with        E4-positive younger LOAD cases. This ???phenotypic extreme??? study design will   maximize our power to identify genetic variants protecting against disease in     E4-positive individuals.